A TAILORED DATABASE COMBINING REFERENCE COMPOUND-DERIVED METABOLITE, METABOLISM PLATFORM AND CHEMICAL CHARACTERISTIC OF CHINESE HERB FOLLOWED BY ACTIVITY SCREENING: APPLICATION TO MAGNOLIAE OFFICINALIS CORTEX

A strategy combining a tailored database and high-throughput activity screening that discover bioactive metabolites derived from Magnoliae Officinalis Cortex (MOC) was developed and implemented to rapidly profile and discover bioactive metabolites in vivo derived from traditional Chinese medicine (TCM).The strategy possessed four characteristics: 1

Toxoplasmosis caused by infection with Toxoplasma gondii is an important parasitic zoonosis with a worldwide distribution.In this study, we examined the functions of two thioredoxins (namely CTrp26 and CTrx1) of T.gondii tachyzoites by generation of HA tag strains or gene deficient parasites in Type I RH strain (ToxoDB#10).Immunofluorescence analys

To solve the practical problem of Stirling engine piston ring, numerical model on friction and lubrication were established caruso rhodiola based on average Reynolds equation theory.Numerical calculation results show: piston rings are in the mixed lubrication state which gas lubrication film and micro-convex body contact existing simultaneously; co

Islamic politics always played a key role in the formation of Indonesian national identity, even 2014 dodge ram 1500 fender flares though Islam was finally compromised in the process of establishing the identity.Islam however was able to give strong influence within Indonesian history.This in turn gives Islam a space to deeply take part in the deve

Abstract In the field of artificial intelligence, a large number of promising tools, such as condition-based maintenance, are available for large internal combustion engines.The cylinder liner, which is a key engine component, is subject to defects due to the manufacturing process.In addition, the cylinder liner straightforwardly affects the usage